Spravato vs Ketamine Infusion Cost: Which Is More Affordable?

Spravato vs Ketamine Infusion: The Cost Breakdown

Trying to decide between Spravato and IV ketamine based on cost? Here's the honest comparison from Next Step Psychiatry.

The Bottom Line

Winner for most patients: Spravato (due to insurance coverage)

Why the Price Difference?

#### Spravato Advantages

• FDA-approved for depression
• Insurance covers it (including Medicare)
• Copay assistance available (as low as $10)
• REMS program ensures safety

#### IV Ketamine Challenges

• Off-label use for depression
• No insurance coverage (almost never)
• No copay assistance programs
• Variable quality control

Real Patient Cost Scenarios

Scenario 1: Good Insurance

• Spravato: $30 copay × 8 induction sessions = $240 total
• IV Ketamine: $500 × 6 infusions = $3,000 total

Scenario 2: High Deductible Plan

• Spravato: ~$500 until deductible, then $30/session
• IV Ketamine: $3,000-$4,800 (counts toward nothing)

Scenario 3: Medicare

• Spravato: Covered (small copay after deductible)
• IV Ketamine: Not covered at all

Total First-Year Costs

Typical treatment includes induction (8 sessions) plus maintenance (24 sessions):

Spravato with Insurance:

• Induction: $240-$800
• Maintenance: $720-$2,400
• Total: $960-$3,200/year

IV Ketamine (No Insurance):

• Initial series: $2,400-$4,800
• Maintenance: $4,800-$9,600
• Total: $7,200-$14,400/year

When Ketamine Might Make Sense

IV ketamine could be preferable if:

• You have no insurance and need immediate relief
• You've tried Spravato without success
• Your insurance denies Spravato coverage
• You prefer IV administration

Our Recommendation

For most patients, Spravato is the more affordable choice thanks to insurance coverage. At Next Step Psychiatry, we help patients navigate coverage to minimize costs.

Get a personalized cost comparison: Contact us or call (678) 437-1659.